Congenital Adrenal Hyperplasia Across the Lifespan
Endocrinologists may face challenges when encountering CAH in patients since it is a relatively uncommon disorder. Using case studies to follow a patient across their lifespan, this KTA aims to address challenges in effectively transitioning adolescent CAH patients into adult care, managing the long-term complexities of the condition, and interpreting evolving and nuanced biochemical markers crucial for the effective management of CAH.
1. Contrast the key management priorities between pediatric and adult patients with CAH, emphasizing clinical differences.
2. Outline a structured approach for transitioning adolescents with CAH to adult care, addressing common challenges in care continuity and patient needs.
3. Identify and manage long-term disease morbidities, such as cardiovascular and metabolic risks, in CAH patients.
Biography:
Dr. Sola Mansour is an endocrinologist in the Division of Endocrinology at the University of Alberta in Edmonton. Her special interests include thyroid disorders. She is an active member of the Continuing Professional Development (CPD) Committee of the Canadian Society of Endocrinology and Metabolism (CSEM).
Conflicts of Interest:
I do not have a relationship with a for-profit and/or a not-for-profit organization to disclose.
Biography:
Dr. Auchus is the James A. Shayman and Andrea S. Kevrick Professor of Translational Medicine in the Departments of Pharmacology and Internal Medicine at the University of Michigan. He also serves as Chief of the Endocrinology Section at the LTC Charles S. Kettles Veterans Affairs Healthcare System. Dr. Auchus and his group are active in a wide range of research projects, including basic biochemical principles and structural biology of steroid biosynthetic enzymes, comprehensive steroid mass spectrometry analysis, and clinical trials and translational investigation in disorders of the pituitary, adrenal, ovaries, and testes that cause hypertension, infertility, and obesity. His clinical interests also focus on pituitary, adrenal, and reproductive diseases that involve disorders of steroid production, and he is particularly interested in the care of adults with genetic disorders of steroid biosynthesis and action. He has authored more than 350 journal articles and 40 book chapters, and he has lectured in a wide range of national and international conferences. He was elected to the Association of American Physicians in 2018 and was chosen to deliver the Lawson Wilkins Lecture for the Pediatric Endocrine Society in 2022. He received the Frontiers in Science & Distinction in Endocrinology Award from the American Association of Clinical Endocrinology in 2023 and was the 2021 recipient of the Outstanding Clinical Investigator Award from the Endocrine Society.
Conflicts of Interest:
Received consulting fees from Quest Diagnostics, Corcept Therapeutics, Xeris Pharmaceuticals, Crinetics Pharmaceuticals,Novo Nordisk, Neurocrine Biosciences/Diurnal LTD, Recordati Rare Diseases, H Lundbeck A/S, and Sparrow Pharmaceuticals. Received research grants from Neurocrine Biosciences/Diurnal LTD, Spruce Biosciences, Corcept Therapeutics, Crinetics Pharmaceuticals, Recordati Rare Diseases, Adrenas Therapeutics, and Mineralys Pharmaceuticals.
Biography:
Mimi Kim
CHLA, Los Angeles, CA
Conflicts of Interest:
Any direct financial payments including receipt of honoraria – UpToDate (Author Royalties for Adrenal Insufficiency chapters)
Membership on advisory boards - Neurocrine Bioscience/Diurnal LTD, Spruce Biosciences, Eton Pharmaceuticals
Funded grants or clinical trials - Neurocrine Bioscience/Diurnal LTD, Spruce Biosciences
Eli Lilly
